Emsam transdermal patches are used to treat major depressive disorder in adults and adolescents who are at least 12 years old. It is provided in the form of a tablet taken by mouth for parkinsons disease and as a patch applied to skin for depression selegiline acts as a monoamine oxidase inhibitor, and increases. Eldepryl selegiline hydrochloride is a levorotatory acetylenic derivative of phenethylamine. Eldepryl product information page 1 of 9 product information eldepryl selegiline hydrochloride name of the medicine eldepryl selegiline hydrochloride is a laevorotatory acetylenic derivative of phenethylamine. Selegiline is an enzyme blocker mao inhibitor that works by slowing the breakdown of certain natural substances in the brain neurotransmitters such as dopamine, norepinephrine, and serotonin. Jul 19, 2017 if your emsam patch falls off, apply a new emsam patch to a new site and follow your normal schedule for changing patches. Easy to read fda package insert, drug facts, dosage and administration, and adverse effects for eldepryl selegiline skip to. Emsam selegiline transdermal uses, side effects, dosage. Side effects can include insomnia, weight loss, and headaches. Requests for emsam selegiline patch may be approved when the following criteria are met. It is usually added to therapy when there is a decrease in response to levodopa. Selegiline transdermal patch emsam for major depressive. Indications and dose parkinsons disease, used alone or as adjunct to cobeneldopa or cocareldopa to reduce end of dose deterioration. Jan 25, 2011 the selegiline transdermal system delivers selegiline to the systemic circulation, avoiding direct inhibition of maoa in the intestine and the firstpass effect in the liver.
This emedtv web page explains how drug interactions with the selegiline transdermal patch can increase your risk of dangerous side effects. If you forget to change your patch after 24 hours, remove the old patch. The package labeling for alora does not specify the presence of any. The greater bioavailability of 6 mg of transdermal selegiline 73% versus 10 mg of oral selegiline 4% is due to the avoidance of the extremely high firstpass metabolism of the oral medication in the gi system and liver before entering the circulatory system. Part of a class of drugs known as monoamine oxidase inhibitors, the medication works by increasing the amount of monoamines in the brain, which improves communication between brain cells. Change your patch 1 time each day at the same time each day. Selegiline hydrochloride, usp is a levorotatory acetylenic derivative of phenethylamine. The selegiline transdermal patch is a prescription medicine approved for the treatment of depression in adults. Selegiline hydrochloride tablets usp package insert selegiline hydrochloride tablets usp 5mg rx only description selegiline hydrochloride is a levorotatory acetylenic derivative of phenethylamine. Aug 01, 2011 if your emsam selegiline transdermal system patch falls off, apply a new emsam patch to a new site and resume your normal schedule for changing patches. Selegiline is a monoamine oxidase inhibitor that works by regulating certain chemicals in the brain. It is commonly referred to in the clinical and pharmacological literature as ldeprenyl.
This updated report found that four cases had completed suicide and four more made suicide attempts. Emsam selegiline transdermal is used to treat major depressive disorder in adults. Nov 09, 2018 to take selegiline orally disintegrating tablets zelapar. In previous clinical studies, up to 12 percent of people taking emsam experienced insomnia, compared to just 7 percent of people not taking emsam. Selegiline, also known as ldeprenyl and sold under the brand names eldepryl and emsam among others, is a medication which is used in the treatment of parkinsons disease and major depressive disorder. This emedtv article offers other important precautions and warnings with selegiline, including information on who should avoid the medication. If you have been taking fluoxetine prozac, sarafem, you must stop taking it for 5 weeks before you begin using selegiline transdermal. When applied to intact skin, emsam is designed to continuously deliver selegiline over a. Selegiline may help people with parkinsons disease by decreasing the dose of levodopacarbidopa. The overall discontinuation rate was 7% for the patch vs.
Selegiline hydrochloride drug bnf content published by. If your dog has been diagnosed with cognitive dysfunction or a neurodegenerative disorder, your veterinarian may prescribe selegiline. The selegiline transdermal system delivers selegiline to the systemic circulation, avoiding direct inhibition of maoa in the intestine and the firstpass effect in the liver. Jul 26, 2017 what other drugs will affect selegiline transdermal emsam. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not. There are two different versions of eldepryl selegiline, a quick dissolving tablet and a regular tablet. Emsam selegiline transdermal system emsam 6 mg9 mg12. It is used with levodopa carbidopa in the treatment of parkinsons disease. Remove the patch from the pouch by tearing at the notches on the sides of the pouch. Emsam selegiline transdermal system package insert.
Selegiline transdermal patch mental health home page. Selegiline prevents the breakdown of chemicals in the brain that are often imbalanced in people with depression. A doubleblind, placebocontrolled trial of the safety and efficacy of selegiline transdermal system without dietary restrictions in patients with major depressive disorder. To take selegiline orally disintegrating tablets zelapar. Concurrent use with tricyclic antidepressantsmay result in asystole,diaphoresis,hypertension,syncope,behav. Selegiline prevents the breakdown of chemicals in the brain that are often imbalanced in people with depression selegiline transdermal is used to treat major depressive disorder in adults and adolescents who are at least 12 years old.
Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Selegiline side effects, dosage, interactions drugs. Taking the selegiline transdermal patch with many cough, cold, and allergy products including eye drops or nasal products can increase your risk of dangerous side effects, such as high blood pressure. Emsam systems are transdermal patches that contain 1 mg of selegiline per. Selegiline increases the actions of dopamine in the brain by inhibiting the enzymes that break it down.
Open the package and peel back the foil from the tablet. Selegiline is a medicine licensed to treat parkinsons disease. Selegiline fda prescribing information, side effects and uses. Apply the patch to dry, smooth skin on the upper back, upper chest, upper thigh, or to the outer part of the upper arm. Emsamsystems are transdermal patches that contain 1 mg of selegiline per cm2and deliver approximately 0. Selegiline can cause several health problems, such as dangerously high blood pressure and hallucinations.
In clinical trials of modafinil, the incidence of rash resulting in discontinuation was approximately 0. Selegiline is a monoamine oxidase type b maob inhibitor prescribed for the management of the symptoms of parkinsons disease in patients already taking levodopacarbidopa also a drug prescribed for the treatment of parkinsons disease selegiline is available under the following different brand names. The most common side effect was an application site reaction 24% of those on the patch vs. By blocking the action of monoamine oxidase in the brain, the medication can help improve the symptoms of depression. Butrans patch buprenorphine patch rationale for inclusion. Many drugs can interact with selegiline, and some drugs should not be used together. Selegiline emsam mylan n n a per mylan representative, patch does not contain aluminum in backing, but mylan cannot comment on the presence of additional metallic content in product due to lack of data. Selegiline hydrochloride drug bnf content published by nice. Drug interactions with the selegiline transdermal patch. Keep the tablet in its blister pack until you are ready to take the medicine. In addition, each capsules contains the following inactive ingredients. If approved, the manufacturer, somerset pharmaceuticals, will market the patch under the trade name emsam. Based on clinical judgment, dose increases should occur in increments of 3 mg per 24 hours up to a maximum dose of 12 mg.
It is provided in the form of a tablet taken by mouth for parkinsons disease and as a patch applied to skin for depression. Transdermal selegiline comes as a patch to apply to the skin. After being sold for years as an antiaging supplement and a treatment for parkinsons disease, the fda approved use of a selegiline transdermal patch emsam for treatment of depression in 2006. Eldepryl selegiline is one of the recommended medicines you can take along with carbidopalevodopa if your parkinsons disease is getting worse. It is usually applied once a day and left in place for 24 hours. Remove your old selegiline patch and apply a new patch at around the same time every day. Rationale for inclusion in pa program background butrans patch is indicated for the management of chronic pain severe enough to require daily, aroundtheclock, longacting opioid treatment for which alternative treatment options are inadequate. Emsam selegiline transdermal system continuous delivery for oncedaily application description emsam selegiline transdermal system is a transdermally administered antidepressant. Emsam selegiline transdermal system is a monoamine oxidase inhibitor. Selegiline should be discontinued 2 wk before ssris are initiated.
Based on clinical judgment, dose increases should occur in increments of 3 mg per 24 hours up to a maximum dose of. Avoid applying to injured, irritated, calloused, or scarred areas. Emsam comes in the form of a patch that is applied daily on the upper torso, upper thigh, or outer arm. Rn,2dimethyln2propynylphenethylamine hydrochloride. Emsam selegiline transdermal system side effects, images. Read the instructions for use at the end of this medication guide for information about the right way to use emsam. When applied to intact skin, emsam is designed to continuously deliver selegiline over a 24hour period. Get emergency medical help if you have signs of an allergic reaction.
The sexual dysfunction rate with emsam was similar to that with placebo, and mean weight change from baseline was minimal. Emsam selegiline prevents the breakdown of chemicals in the brain that are often imbalanced in people with depression. Average aucinf nghrml of selegiline and the three major metabolites estimated for a single, 24hour application of an emsam 6 mg24 hours patch and a single, 10 mg oral immediate release dose of selegiline hcl in 12 healthy male and female. Transdermal patches for the treatment of neurologic. Treatment refractory patients were randomly assigned to openlabel treatment.
Most of these products should never be taken with the selegiline transdermal patch. Ssris and snris are among the drugs that can potentially interact with the selegiline transdermal patch. If you forget to change your patch after 24 hours, remove the old patch, put on a new patch in a different area and continue to follow your original schedule. Emsam selegiline transdermal system product characteristics. Use emsam exactly as your healthcare provider tells you to use it. Feb 15, 2008 selegiline transdermal patch emsam patch with a dose of 6 mg per 24 hours applied each day. Apply your patch right after you open the sealed pouch. Jan 22, 2020 emsam selegiline prevents the breakdown of chemicals in the brain that are often imbalanced in people with depression. Each capsule, for oral administration contains 5 mg of selegiline hydrochloride. This updated report found that four cases had completed. Emsam is a drug that is licensed to treat depression.
Emsam should be applied to dry, intact skin on the upper torso below the neck and above the waist, upper thigh or the outer surface of the upper arm once every 24 hours. Butrans is a topical patch which provides timereleased delivery of buprenorphine, a. Each corresponding system has an active surface area of 20 cm. Jul 26, 2017 emsam transdermal systems are available in three strengths that deliver approximately 6 mg, 9 mg, or 12 mg of selegiline over 24 hours. An introduction to trouble sleeping with emsam trouble sleeping is a common side effect of emsam selegiline transdermal patch. It is commonly referred to in the clinical and pharmacological literature as l deprenyl. Put on a new patch in a different area and continue to follow your normal schedule for changing patches. Emsam selegiline transdermal system emsam 6 mg9 mg12 mg.
Read the medication guide available from your pharmacist before you start using selegiline and each time you get a refill. Using extra skin patches will not make the medication more effective. Emsam continues to be released from the patch and this may be a potential. It is used with levodopacarbidopa in the treatment of parkinsons disease. The recommended starting dose and target dose for emsam is 6 mg per 24 hours. Emsam may also be used for purposes not listed in this medication guide. Transdermal selegiline for the treatment of major depressive disorder. This emedtv resource explains how selegiline works to increase dopamine levels, lists potential side effects of the medication, and provides some tips on when and how to take the drug. Indications and dose parkinsons disease, used alone or as adjunct to cobeneldopa or cocareldopa to reduce end of dose deterioration, symptomatic parkinsonism. Information for the user eldepryl 5 mg tablets eldepryl 10 mg tablets selegiline hydrochloride read all of this leaflet carefully before you start taking this medicine because it contains important information for you. Selegiline fda prescribing information, side effects and. Easy to read fda package insert, drug facts, dosage and administration, and adverse effects for eldepryl selegiline. Do not wear more than one selegiline patch at a time. The selegiline patch would be the first transdermal medication approved to treat depression, and the 20mg formulation would be the first mao inhibitor approved for treating depression without dietary tyramine restrictions.
1103 976 961 293 1437 290 1108 1122 400 234 631 870 832 138 1221 200 353 1390 1199 195 251 1085 575 1005 751 1389 712 961 633 395 669 191 822